An Optimized Workflow for the Discovery of New Antimicrobial Compounds Targeting Bacterial RNA Polymerase Complex Formation

An Optimized Workflow for the Discovery of New Antimicrobial Compounds Targeting Bacterial RNA Polymerase Complex Formation

Bacterial resistance represents a major health problem worldwide and there is an urgent need to develop first-in-class compounds directed against new therapeutic targets. We previously developed a drug-discovery platform to identify new antimicrobials able to disrupt the protein–protein interaction...

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Bibliographic Details
Main Authors: Alessia Caputo, Sara Sartini, Elisabetta Levati, Ilaria Minato, Gian Marco Elisi, Adriana Di Stasi, Catherine Guillou, Peter G. Goekjian, Pierre Garcia, David Gueyrard, Stéphane Bach, Arnaud Comte, Simone Ottonello, Silvia Rivara, Barbara Montanini
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Antibiotics
Subjects:
yeast Bioluminescence Resonance Energy Transfer (yBRET)
protein–protein interaction (PPI)
protein–protein interaction inhibitor
bacterial RNA polymerase (RNAP)
RNAP holoenzyme assembly
bacterial transcription inhibitors
Online Access:https://www.mdpi.com/2079-6382/11/10/1449

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https://www.mdpi.com/2079-6382/11/10/1449

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