Investigating Novel Therapeutic Approaches for Idiopathic Short Stature: Targeting siRNA and Growth Hormone Delivery to the Growth Plate Using Exosome Nanoparticles

Investigating Novel Therapeutic Approaches for Idiopathic Short Stature: Targeting siRNA and Growth Hormone Delivery to the Growth Plate Using Exosome Nanoparticles

Abstract Idiopathic short stature (ISS) is a common childhood condition with largely unknown underlying causes. Recent research highlights the role of circulating exosomes in the pathogenesis of various disorders, but their connection to ISS remains unexplored. In the experiments, human chondrocytes...

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Bibliographic Details
Main Authors: Jinghong Yuan, Yameng Wang, Yanzhe Huang, Shengqin Li, Xiaowen Zhang, Zhiwen Wu, Wenrui Zhao, Junchao Zhu, Junqiu Zhang, Guowen Huang, Peng Yu, Xigao Cheng, Xinhui Wang, Xijuan Liu, Jingyu Jia
Format: Article
Language:English
Published: Wiley 2024-06-01
Series:Advanced Science
Subjects:
bone growth
exosome
growth plate
idiopathic short stature
long noncoding RNA
Online Access:https://doi.org/10.1002/advs.202309559

Internet

https://doi.org/10.1002/advs.202309559

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