Mirk/Dyrk1B mediates G0/G1 to S phase cell cycle progression and cell survival involving MAPK/ERK signaling in human cancer cells

Mirk/Dyrk1B mediates G0/G1 to S phase cell cycle progression and cell survival involving MAPK/ERK signaling in human cancer cells

<p>Abstract</p> <p>Background</p> <p>Mirk/Dyrk1B contributes to G0 arrest by destabilization of cyclin D1 and stabilization of p27kip1 to maintain the viability of quiescent human cancer cells, and it could be negatively regulated by mitogenic-activated protein kinase (...

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Bibliographic Details
Main Authors: Gao Jingchun, Zhao Yi, Lv Yunyi, Chen Yamin, Wei Bing, Tian Jianxin, Yang Zhihai, Kong Fandou, Pang Jian, Liu Jiwei, Shi Hong
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Cancer Cell International
Subjects:
Mirk/Dyrk1B
MAPK/ERK
siRNA
Cell cycle
Cancer cells
Online Access:http://www.cancerci.com/content/13/1/2

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http://www.cancerci.com/content/13/1/2

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