The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis

The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis

Abstract Background Scleroderma (SSc) is a rare autoimmune disease characterized by vascular impairment and progressive fibrosis of the skin and other organs. Oncostatin M, a member of the IL-6 family, is elevated in SSc serum and was recognized as a significant player in various stages of fibrosis....

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Bibliographic Details
Main Authors: G. Marden, Q. Wan, J. Wilks, K. Nevin, M. Feeney, N. Wisniacki, M. Trojanowski, A. Bujor, L. Stawski, M. Trojanowska
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Arthritis Research & Therapy
Subjects:
OSM
OSMRβ
IL-6
Endothelial cells
SSc
FLI1
Online Access:http://link.springer.com/article/10.1186/s13075-020-02266-0

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http://link.springer.com/article/10.1186/s13075-020-02266-0

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