An Electrophysiological and Proteomic Analysis of the Effects of the Superoxide Dismutase Mimetic, MnTMPyP, on Synaptic Signalling Post-Ischemia in Isolated Rat Hippocampal Slices

An Electrophysiological and Proteomic Analysis of the Effects of the Superoxide Dismutase Mimetic, MnTMPyP, on Synaptic Signalling Post-Ischemia in Isolated Rat Hippocampal Slices

Metabolic stress and the increased production of reactive oxygen species (ROS) are two main contributors to neuronal damage and synaptic plasticity in acute ischemic stroke. The superoxide scavenger MnTMPyP has been previously reported to have a neuroprotective effect in organotypic hippocampal slic...

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Bibliographic Details
Main Authors: Martina Puzio, Niamh Moreton, Mairéad Sullivan, Caitriona Scaife, Jeffrey C. Glennon, John J. O’Connor
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Antioxidants
Subjects:
hypoxia
oxygen–glucose deprivation
hippocampus
EPSP
superoxide dismutase
ischemia-reperfusion injury
Online Access:https://www.mdpi.com/2076-3921/12/4/792

Internet

https://www.mdpi.com/2076-3921/12/4/792

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