Comparing synaptic proteomes across five mouse models for autism reveals converging molecular similarities including deficits in oxidative phosphorylation and Rho GTPase signaling

Comparing synaptic proteomes across five mouse models for autism reveals converging molecular similarities including deficits in oxidative phosphorylation and Rho GTPase signaling

Specific and effective treatments for autism spectrum disorder (ASD) are lacking due to a poor understanding of disease mechanisms. Here we test the idea that similarities between diverse ASD mouse models are caused by deficits in common molecular pathways at neuronal synapses. To do this, we levera...

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Bibliographic Details
Main Authors: Abigail U. Carbonell, Carmen Freire-Cobo, Ilana V. Deyneko, Saunil Dobariya, Hediye Erdjument-Bromage, Amy E. Clipperton-Allen, Damon T. Page, Thomas A. Neubert, Bryen A. Jordan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
proteomic convergence
PSD
Rho GTPase
Rac
tandem mass tags
TMT
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1152562/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1152562/full

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