Broad susceptibility of Candida auris strains to 8-hydroxyquinolines and mechanisms of resistance

Broad susceptibility of Candida auris strains to 8-hydroxyquinolines and mechanisms of resistance

ABSTRACT The fungal pathogen Candida auris represents a severe threat to hospitalized patients. Its resistance to multiple classes of antifungal drugs and ability to spread and resist decontamination in healthcare settings make it especially dangerous. We screened 1,990 clinically approved and late-...

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Bibliographic Details
Main Authors: Matthew B. Lohse, Matthew T. Laurie, Sophia Levan, Naomi Ziv, Craig L. Ennis, Clarissa J. Nobile, Joseph DeRisi, Alexander D. Johnson
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mBio
Subjects:
Candida auris
antifungal resistance
dihalogenated 8-hydroxyquinolines
broxyquinoline
chloroxine
clioquinol
Online Access:https://journals.asm.org/doi/10.1128/mbio.01376-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01376-23

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