Assessing the effects of aging on the renal endothelial cell landscape using single-cell RNA sequencing

Endothelial cells (ECs) with senescence-associated secretory phenotypes (SASP) have been identified as a key mechanism of aging that contributes to various age-related kidney diseases. In this study, we used single-cell RNA sequencing (scRNA-seq) to create a transcriptome atlas of murine renal ECs a...

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Bibliographic Details
Main Authors: Mengke Li, Dongliang Wang, Zhong Liu, Yanjing Huang, Qikai Zhang, Caineng Pan, Yuheng Lin, Li Sun, Yingfeng Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1175716/full