Gene Coverage Count and Classification (GC3): a locus sequence coverage assessment tool using short-read whole genome sequencing data, and its application to identify and classify histidine-rich protein 2 and 3 deletions in Plasmodium falciparum

Gene Coverage Count and Classification (GC3): a locus sequence coverage assessment tool using short-read whole genome sequencing data, and its application to identify and classify histidine-rich protein 2 and 3 deletions in Plasmodium falciparum

Abstract Background The ability of malaria rapid diagnostic tests (RDTs) to effectively detect active infections is being compromised by the presence of malaria strains with genomic deletions at the hrp2 and hrp3 loci, encoding the antigens most commonly targeted in diagnostics for Plasmodium falcip...

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Bibliographic Details
Main Authors: Thomas C. Stabler, Ankit Dwivedi, Biraj Shrestha, Sudhaunshu Joshi, Tobias Schindler, Amed Ouattara, Guillermo A. García, Claudia Daubenberger, Joana C. Silva
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Malaria Journal
Subjects:
Malaria
Rapid Diagnostic Test
hrp2
hrp3
Deletion
Gene coverage
Online Access:https://doi.org/10.1186/s12936-022-04376-3

Internet

https://doi.org/10.1186/s12936-022-04376-3

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