Free Polyethylenimine Enhances Substrate-Mediated Gene Delivery on Titanium Substrates Modified With RGD-Functionalized Poly(acrylic acid) Brushes

Free Polyethylenimine Enhances Substrate-Mediated Gene Delivery on Titanium Substrates Modified With RGD-Functionalized Poly(acrylic acid) Brushes

Substrate mediated gene delivery (SMD) is a method of immobilizing DNA complexes to a substrate via covalent attachment or nonspecific adsorption, which allows for increased transgene expression with less DNA compared to traditional bolus delivery. It may also increase cells receptivity to transfect...

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Bibliographic Details
Main Authors: Amy Mantz, Alice Rosenthal, Eric Farris, Tyler Kozisek, Eva Bittrich, Saghar Nazari, Eva Schubert, Mathias Schubert, Manfred Stamm, Petra Uhlmann, Angela K. Pannier
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Chemistry
Subjects:
substrate mediated
polymer brushes
poly(acrylic) acid
nonviral gene delivery
branched polyethylenimine
RGD ligand
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00051/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00051/full

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