Large-scale bioreactor production of extracellular vesicles from mesenchymal stromal cells for treatment of acute radiation syndrome

Large-scale bioreactor production of extracellular vesicles from mesenchymal stromal cells for treatment of acute radiation syndrome

Abstract Background Hematopoietic acute radiation syndrome (H-ARS) occurring after exposure to ionizing radiation damages bone marrow causing cytopenias, increasing susceptibility to infections and death. We and others have shown that cellular therapies like human mesenchymal stromal cells (MSCs), o...

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Bibliographic Details
Main Authors: John A. Kink, Michael A. Bellio, Matthew H. Forsberg, Alexandra Lobo, Anna S. Thickens, Bryson M. Lewis, Irene M. Ong, Aisha Khan, Christian M. Capitini, Peiman Hematti
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Stem Cell Research & Therapy
Subjects:
Extracellular vesicles
Exosomes
Mesenchymal stromal cells
TLR4
Acute radiation syndrome
Online Access:https://doi.org/10.1186/s13287-024-03688-2

Internet

https://doi.org/10.1186/s13287-024-03688-2

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