TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3

TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3

SUMMARY Although it is known that tumor necrosis factor receptor (TNFR) signaling plays a crucial role in vascular integrity and homeostasis, the contribution of each receptor to these processes and the signaling pathway involved are still largely unknown. Here, we show that targeted gene knockdown...

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Bibliographic Details
Main Authors: Raquel Espín, Francisco J. Roca, Sergio Candel, María P. Sepulcre, Juan M. González-Rosa, Francisca Alcaraz-Pérez, José Meseguer, María L. Cayuela, Nadia Mercader, Victoriano Mulero
Format: Article
Language:English
Published: The Company of Biologists 2013-03-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/6/2/383

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http://dmm.biologists.org/content/6/2/383

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