TDP-43 pathology is sufficient to drive axon initial segment plasticity and hyperexcitability of spinal motoneurones in vivo in the TDP43-ΔNLS model of Amyotrophic Lateral Sclerosis

Abstract A hyperexcitability of the motor system is consistently observed in Amyotrophic Lateral Sclerosis (ALS) and has been implicated in the disease pathogenesis. What drives this hyperexcitability in the vast majority of patients is unknown. This is important to know as existing treatments simpl...

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Bibliographic Details
Main Authors: Svetlana Djukic, Zhenxiang Zhao, Lasse Mathias Holmsted Jørgensen, Anna Normann Bak, Dennis Bo Jensen, Claire Francesca Meehan
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Acta Neuropathologica Communications
Subjects:
Online Access:https://doi.org/10.1186/s40478-025-01934-z