8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase–hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases. We identified QN 19, a simple, low molecular weigh...

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Bibliographic Details
Main Authors: Damijan Knez, Daniel Diez-Iriepa, Mourad Chioua, Andrea Gottinger, Milica Denic, Fabien Chantegreil, Florian Nachon, Xavier Brazzolotto, Anna Skrzypczak-Wiercioch, Anže Meden, Anja Pišlar, Janko Kos, Simon Žakelj, Jure Stojan, Kinga Sałat, Julia Serrano, Ana Patricia Fernández, Aitana Sánchez-García, Ricardo Martínez-Murillo, Claudia Binda, Francisco López-Muñoz, Stanislav Gobec, José Marco-Contelles
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Quinolylnitrone
Butyrylcholinesterase
Monoamine oxidase B
Alzheimer's disease
Multifunctional ligands
6-Hydroxydopamine model
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523000138

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http://www.sciencedirect.com/science/article/pii/S2211383523000138

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