The HSP90 Inhibitor, AUY-922, Protects and Repairs Human Lung Microvascular Endothelial Cells from Hydrochloric Acid-Induced Endothelial Barrier Dysfunction

The HSP90 Inhibitor, AUY-922, Protects and Repairs Human Lung Microvascular Endothelial Cells from Hydrochloric Acid-Induced Endothelial Barrier Dysfunction

Exposure to hydrochloric acid (HCl) leads acutely to asthma-like symptoms, acute respiratory distress syndrome (ARDS), including compromised alveolo-capillary barrier, and respiratory failure. To better understand the direct effects of HCl on pulmonary endothelial function, we studied the characteri...

Full description

Bibliographic Details
Main Authors: Ruben M. L. Colunga Biancatelli, Pavel Solopov, Betsy Gregory, John D. Catravas
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
acidosis
hydrochloric acid
HCl
endothelial dysfunction
heat shock protein
HSP90 inhibition
Online Access:https://www.mdpi.com/2073-4409/10/6/1489

Similar Items

Similar Items