Pegasus, a small extracellular peptide enhancing short-range diffusion of Wingless

Short open reading frames (smORFs) of less than 100 codons exist in the thousands in metazoan genomes, mostly with yet unknown functions. Here the authors show how a smORF conserved from flies to vertebrates produces a secreted peptide that enhances the diffusion of the cell signalling protein Wingl...

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Bibliographic Details
Main Authors: Emile G. Magny, Ana Isabel Platero, Sarah A. Bishop, Jose I. Pueyo, Daniel Aguilar-Hidalgo, Juan Pablo Couso
Format: Article
Language:English
Published: Nature Portfolio 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25785-z