Structural Transition States Explored With Minimalist Coarse Grained Models: Applications to Calmodulin

Transitions between different conformational states are ubiquitous in proteins, being involved in signaling, catalysis, and other fundamental activities in cells. However, modeling those processes is extremely difficult, due to the need of efficiently exploring a vast conformational space in order t...

Full description

Bibliographic Details
Main Authors: Francesco Delfino, Yuri Porozov, Eugene Stepanov, Gaik Tamazian, Valentina Tozzini
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00104/full