Inhibitors of One or More Cellular Aurora Kinases Impair the Replication of Herpes Simplex Virus 1 and Other DNA and RNA Viruses with Diverse Genomes and Life Cycles

Inhibitors of One or More Cellular Aurora Kinases Impair the Replication of Herpes Simplex Virus 1 and Other DNA and RNA Viruses with Diverse Genomes and Life Cycles

ABSTRACT We utilized a high-throughput cell-based assay to screen several chemical libraries for inhibitors of herpes simplex virus 1 (HSV-1) gene expression. From this screen, four aurora kinase inhibitors were identified that potently reduced gene expression during HSV-1 lytic infection. HSV-1 is...

Full description

Bibliographic Details
Main Authors: Cindy Y. Ly, Jessica Pfannenstiel, Anil Pant, Zhilong Yang, Anthony R. Fehr, Maxim S. Rodzkin, David J. Davido
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
herpesvirus
HSV-1
aurora kinases
kinase inhibitors
coronavirus
poxvirus
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01943-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.01943-22

Similar Items