Chimeric Antigen Receptor-T Cell Therapy

Abstract. Chimeric antigen receptor (CAR)-T cell therapy is a new class of cellular immunotherapies that involves ex vivo genetic modification of T cells to incorporate an engineered CAR. After infusion into the patient, the CAR-expressing T cells recognize specific tumor targets and induce an immun...

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Bibliographic Details
Main Authors: Jochen Buechner, Marie José Kersten, Miriam Fuchs, Florence Salmon, Ulrich Jäger
Format: Article
Language:English
Published: Wiley 2018-02-01
Series:HemaSphere
Online Access:http://journals.lww.com/10.1097/HS9.0000000000000018