Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody

Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody

Abstract An essential step for SARS‐CoV‐2 infection is the attachment to the host cell receptor by its Spike receptor‐binding domain (RBD). Most of the existing RBD‐targeting neutralizing antibodies block the receptor‐binding motif (RBM), a mutable region with the potential to generate neutralizatio...

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Bibliographic Details
Main Authors: Tingting Li, Hongmin Cai, Yapei Zhao, Yanfang Li, Yanling Lai, Hebang Yao, Liu Daisy Liu, Zhou Sun, Martje Fentener van Vlissingen, Thijs Kuiken, Corine H GeurtsvanKessel, Ning Zhang, Bingjie Zhou, Lu Lu, Yuhuan Gong, Wenming Qin, Moumita Mondal, Bowen Duan, Shiqi Xu, Audrey S Richard, Hervé Raoul, JianFeng Chen, Chenqi Xu, Ligang Wu, Haisheng Zhou, Zhong Huang, Xuechao Zhang, Jun Li, Yanyan Wang, Yuhai Bi, Barry Rockx, Junfang Chen, Fei‐Long Meng, Dimitri Lavillette, Dianfan Li
Format: Article
Language:English
Published: Springer Nature 2021-12-01
Series:EMBO Molecular Medicine
Subjects:
COVID‐19
cross‐active neutralizing antibody
destruction of spike
receptor‐binding domain
variants of concern
Online Access:https://doi.org/10.15252/emmm.202114544

Internet

https://doi.org/10.15252/emmm.202114544

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