Bioprocessing of camptothecin from Alternaria brassicicola, an endophyte of Catharanthus roseus, with a strong antiproliferative activity and inhibition to Topoisomerases

Bioprocessing of camptothecin from Alternaria brassicicola, an endophyte of Catharanthus roseus, with a strong antiproliferative activity and inhibition to Topoisomerases

Abstract Suppression of fungal camptothecin (CPT) biosynthesis with the preservation and successive subculturing is the challenge that impedes fungi from the industrial application, so, screening for a novel fungal isolate with a conceivable stable producing potency of CPT was the main objective of...

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Bibliographic Details
Main Authors: Nouran A. A. Abd El-Hady, Abdelaleim I. ElSayed, Khalid M. Wadan, Sayed S. El-Saadany, Ashraf S. A. El-Sayed
Format: Article
Language:English
Published: BMC 2024-07-01
Series:Microbial Cell Factories
Subjects:
Camptothecin
Alternaria brassicicola
Catharanthus roseus
Anticancer activity
Topoisomerase inhibitors
Apoptosis
Online Access:https://doi.org/10.1186/s12934-024-02471-5

Internet

https://doi.org/10.1186/s12934-024-02471-5

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