A <i>Toxoplasma gondii</i> Oxopurine Transporter Binds Nucleobases and Nucleosides Using Different Binding Modes

A <i>Toxoplasma gondii</i> Oxopurine Transporter Binds Nucleobases and Nucleosides Using Different Binding Modes

<i>Toxoplasma gondii</i> is unable to synthesize purines de novo, instead salvages them from its environment, inside the host cell, for which they need high affinity carriers. Here, we report the expression of a <i>T. gondii</i> Equilibrative Nucleoside Transporter, Tg244440,...

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Bibliographic Details
Main Authors: Gustavo D. Campagnaro, Hamza A. A. Elati, Sofia Balaska, Maria Esther Martin Abril, Manal J. Natto, Fabian Hulpia, Kelly Lee, Lilach Sheiner, Serge Van Calenbergh, Harry P. de Koning
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Toxoplasma gondii</i>
purine transporter
Tg244440
nucleobase transporter
apicomplexan
substrate binding
Online Access:https://www.mdpi.com/1422-0067/23/2/710

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https://www.mdpi.com/1422-0067/23/2/710

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