Gene amplification‐driven RNA methyltransferase KIAA1429 promotes tumorigenesis by regulating BTG2 via m6A‐YTHDF2‐dependent in lung adenocarcinoma

Gene amplification‐driven RNA methyltransferase KIAA1429 promotes tumorigenesis by regulating BTG2 via m6A‐YTHDF2‐dependent in lung adenocarcinoma

Abstract Background Epigenetic alterations have been shown to contribute immensely to human carcinogenesis. Dynamic and reversible N6‐methyladenosine (m6A) RNA modification regulates gene expression and cell fate. However, the reasons for activation of KIAA1429 (also known as VIRMA, an RNA methyltra...

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Bibliographic Details
Main Authors: Chang Zhang, Qi Sun, Xu Zhang, Na Qin, Zhening Pu, Yayun Gu, Caiwang Yan, Meng Zhu, Juncheng Dai, Cheng Wang, Ni Li, Guangfu Jin, Hongxia Ma, Zhibin Hu, Erbao Zhang, Fengwei Tan, Hongbing Shen
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Cancer Communications
Subjects:
BTG2
gene amplification
KIAA1429
LUAD
mRNA stability
N6‐methyladenosine
Online Access:https://doi.org/10.1002/cac2.12325

Internet

https://doi.org/10.1002/cac2.12325

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