A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis.

A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis.

The emergence of diseases associated with telomere dysfunction, including AIDS, aplastic anemia and pulmonary fibrosis, has bolstered interest in telomerase activators. We report identification of a new small molecule activator, GRN510, with activity ex vivo and in vivo. Using a novel mouse model, w...

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Bibliographic Details
Main Authors: Claude Jourdan Le Saux, Philip Davy, Christopher Brampton, Seema S Ahuja, Steven Fauce, Pooja Shivshankar, Hieu Nguyen, Mahesh Ramaseshan, Robert Tressler, Zhu Pirot, Calvin B Harley, Richard Allsopp
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3597721?pdf=render

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http://europepmc.org/articles/PMC3597721?pdf=render

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