Structural basis of human PRPS2 filaments

Structural basis of human PRPS2 filaments

Abstract Background PRPP synthase (PRPS) transfers the pyrophosphate groups from ATP to ribose-5-phosphate to produce 5-phosphate ribose-1-pyrophosphate (PRPP), a key intermediate in the biosynthesis of several metabolites including nucleotides, dinucleotides and some amino acids. There are three PR...

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Bibliographic Details
Main Authors: Guang-Ming Lu, Huan-Huan Hu, Chia-Chun Chang, Jiale Zhong, Xian Zhou, Chen-Jun Guo, Tianyi Zhang, Yi-Lan Li, Boqi Yin, Ji-Long Liu
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Cell & Bioscience
Subjects:
PRPS
PRPP
Cytoophidium
hPRPS2
Cryo-EM
Allosteric regulation
Online Access:https://doi.org/10.1186/s13578-023-01037-z

Internet

https://doi.org/10.1186/s13578-023-01037-z

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