Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4

Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4

Antimitotic drugs that target tubulin are among the most widely used chemotherapeutic agents; however, the development of multidrug resistance has limited their clinical activity. We report the synthesis and biological properties of a series of novel 3-chloro-β-lactams and 3,3-dichloro-β-lactams (2-...

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Bibliographic Details
Main Authors: Azizah M. Malebari, Shu Wang, Thomas F. Greene, Niamh M. O’Boyle, Darren Fayne, Mohemmed Faraz Khan, Seema M. Nathwani, Brendan Twamley, Thomas McCabe, Daniela M. Zisterer, Mary J. Meegan
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceuticals
Subjects:
β-lactam
3-chloroazetidin-2-ones
antimitotic
antiproliferative activity
breast cancer
tubulin polymerisation
Online Access:https://www.mdpi.com/1424-8247/14/11/1119

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https://www.mdpi.com/1424-8247/14/11/1119

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