Synthesis, antiinflammatory activity, and molecular docking studies of bisphosphonic esters as potential MMP-8 and MMP-9 inhibitors

Synthesis, antiinflammatory activity, and molecular docking studies of bisphosphonic esters as potential MMP-8 and MMP-9 inhibitors

Bisphosphonic acids (or bisphosphonates) have been successfully used in the clinic treatment of bone diseases for over decades. Additionally, the antiinflammatory activity of these compounds has been gaining attention. In our previous work, we synthesized and in vivo evaluated the bisphosphonic este...

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Bibliographic Details
Main Authors: Abimelek Cortes-Pacheco, María Adelina Jiménez-Arellanes, Francisco José Palacios-Can, José Antonio Valcarcel-Gamiño, Rodrigo Said Razo-Hernández, María del Carmen Juárez-Vázquez, Adolfo López-Torres, Oscar Abelardo Ramírez-Marroquín
Format: Article
Language:English
Published: Beilstein-Institut 2020-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
inflammation
molecular docking
organophosphorus compounds
Online Access:https://doi.org/10.3762/bjoc.16.108

Internet

https://doi.org/10.3762/bjoc.16.108

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