Intraportally delivered stem cell spheroids localize in the liver and protect hepatocytes against GalN/LPS-induced fulminant hepatic toxicity

Intraportally delivered stem cell spheroids localize in the liver and protect hepatocytes against GalN/LPS-induced fulminant hepatic toxicity

Abstract Background Systemic inflammatory response syndrome (SIRS) is common in severe fulminant hepatic failure (FHF) and has a high mortality rate (20–50%) due to irreversible cerebral edema or sepsis. Stem cell-based treatment has emerged as a promising alternative therapeutic strategy to prolong...

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Bibliographic Details
Main Authors: Shobha Regmi, Shiva Pathak, Tung Pham Thanh, Tiep Tien Nguyen, Jong-Hyuk Sung, Simmyung Yook, Jong Oh. Kim, Chul Soon Yong, Inho Choi, Kyoung-Oh Doh, Pil-Hoon Park, Jun-Beom Park, Yoojin Seo, Bieong-Kil Kim, Dong-Mok Lee, Ik-Jae Moon, Hyung-Sik Kim, Jee-Heon Jeong
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cell
2D-cultured cells
Spheroids
Intraportal delivery
Fulminant hepatic failure
Online Access:http://link.springer.com/article/10.1186/s13287-019-1337-3

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http://link.springer.com/article/10.1186/s13287-019-1337-3

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