High-throughput prediction of protein conformational distributions with subsampled AlphaFold2

Abstract This paper presents an innovative approach for predicting the relative populations of protein conformations using AlphaFold 2, an AI-powered method that has revolutionized biology by enabling the accurate prediction of protein structures. While AlphaFold 2 has shown exceptional accuracy and...

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Bibliographic Details
Main Authors: Gabriel Monteiro da Silva, Jennifer Y. Cui, David C. Dalgarno, George P. Lisi, Brenda M. Rubenstein
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46715-9