The Role and Function of Ras-association domain family in Cancer: A Review

Ras gene mutation has been observed in more than 30% of cancers, and 90% of pancreatic, lung and colon cancers. Ras proteins (K-Ras, H-Ras, N-Ras) act as molecular switches which are activated by binding to GTP. They play a role in the cascade of cell process control (proliferation and cell division...

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Main Authors: Mohammad Reza Zinatizadeh, Seyed Ali Momeni, Peyman Kheirandish Zarandi, Ghanbar Mahmoodi Chalbatani, Hassan Dana, Hamid Reza Mirzaei, Mohammad Esmaeil Akbari, Seyed Rouhollah Miri
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2019-12-01
Series:Genes and Diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304219300522