The Role and Function of Ras-association domain family in Cancer: A Review
Ras gene mutation has been observed in more than 30% of cancers, and 90% of pancreatic, lung and colon cancers. Ras proteins (K-Ras, H-Ras, N-Ras) act as molecular switches which are activated by binding to GTP. They play a role in the cascade of cell process control (proliferation and cell division...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2019-12-01
|
| Series: | Genes and Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304219300522 |
| _version_ | 1797717956874993664 |
|---|---|
| author | Mohammad Reza Zinatizadeh Seyed Ali Momeni Peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani Hassan Dana Hamid Reza Mirzaei Mohammad Esmaeil Akbari Seyed Rouhollah Miri |
| author_facet | Mohammad Reza Zinatizadeh Seyed Ali Momeni Peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani Hassan Dana Hamid Reza Mirzaei Mohammad Esmaeil Akbari Seyed Rouhollah Miri |
| author_sort | Mohammad Reza Zinatizadeh |
| collection | DOAJ |
| description | Ras gene mutation has been observed in more than 30% of cancers, and 90% of pancreatic, lung and colon cancers. Ras proteins (K-Ras, H-Ras, N-Ras) act as molecular switches which are activated by binding to GTP. They play a role in the cascade of cell process control (proliferation and cell division). In the inactive state, transforming GTP to GDP leads to the activation of GTpase in Ras gene. However, the mutation in Ras leads to the loss of internal GTPase activity and permanent activation of the protein. The activated Ras can promote the cell death or stop cell growth, which are facilitated by Ras-association domain family. Various studies have been conducted to determine the importance of losing RASSF proteins in Ras-induced tumors. This paper examines the role of Ras and RASSF proteins. In general, RASSF proteins can be used as a suitable means for targeting a large group of Ras-induced tumors. Keywords: Cancer, Colon, H-Ras, K-Ras, Lung, N-Ras, Pancreatic |
| first_indexed | 2024-03-12T08:43:57Z |
| format | Article |
| id | doaj.art-7f2fc98869a1419c9cdb3a96460a43a0 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T08:43:57Z |
| publishDate | 2019-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-7f2fc98869a1419c9cdb3a96460a43a02023-09-02T16:33:50ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422019-12-0164378384The Role and Function of Ras-association domain family in Cancer: A ReviewMohammad Reza Zinatizadeh0Seyed Ali Momeni1Peyman Kheirandish Zarandi2Ghanbar Mahmoodi Chalbatani3Hassan Dana4Hamid Reza Mirzaei5Mohammad Esmaeil Akbari6Seyed Rouhollah Miri7Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran; Corresponding author. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Uro-Oncology Research Center, Tehran University of Medical Sciences, Tehran, IR, IranCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, IranCancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, IranCancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, IranCancer Research Center, Shohadae Tajrish Hospital, Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, IranCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranCancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran; Corresponding author. Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, IranRas gene mutation has been observed in more than 30% of cancers, and 90% of pancreatic, lung and colon cancers. Ras proteins (K-Ras, H-Ras, N-Ras) act as molecular switches which are activated by binding to GTP. They play a role in the cascade of cell process control (proliferation and cell division). In the inactive state, transforming GTP to GDP leads to the activation of GTpase in Ras gene. However, the mutation in Ras leads to the loss of internal GTPase activity and permanent activation of the protein. The activated Ras can promote the cell death or stop cell growth, which are facilitated by Ras-association domain family. Various studies have been conducted to determine the importance of losing RASSF proteins in Ras-induced tumors. This paper examines the role of Ras and RASSF proteins. In general, RASSF proteins can be used as a suitable means for targeting a large group of Ras-induced tumors. Keywords: Cancer, Colon, H-Ras, K-Ras, Lung, N-Ras, Pancreatichttp://www.sciencedirect.com/science/article/pii/S2352304219300522 |
| spellingShingle | Mohammad Reza Zinatizadeh Seyed Ali Momeni Peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani Hassan Dana Hamid Reza Mirzaei Mohammad Esmaeil Akbari Seyed Rouhollah Miri The Role and Function of Ras-association domain family in Cancer: A Review Genes and Diseases |
| title | The Role and Function of Ras-association domain family in Cancer: A Review |
| title_full | The Role and Function of Ras-association domain family in Cancer: A Review |
| title_fullStr | The Role and Function of Ras-association domain family in Cancer: A Review |
| title_full_unstemmed | The Role and Function of Ras-association domain family in Cancer: A Review |
| title_short | The Role and Function of Ras-association domain family in Cancer: A Review |
| title_sort | role and function of ras association domain family in cancer a review |
| url | http://www.sciencedirect.com/science/article/pii/S2352304219300522 |
| work_keys_str_mv | AT mohammadrezazinatizadeh theroleandfunctionofrasassociationdomainfamilyincancerareview AT seyedalimomeni theroleandfunctionofrasassociationdomainfamilyincancerareview AT peymankheirandishzarandi theroleandfunctionofrasassociationdomainfamilyincancerareview AT ghanbarmahmoodichalbatani theroleandfunctionofrasassociationdomainfamilyincancerareview AT hassandana theroleandfunctionofrasassociationdomainfamilyincancerareview AT hamidrezamirzaei theroleandfunctionofrasassociationdomainfamilyincancerareview AT mohammadesmaeilakbari theroleandfunctionofrasassociationdomainfamilyincancerareview AT seyedrouhollahmiri theroleandfunctionofrasassociationdomainfamilyincancerareview AT mohammadrezazinatizadeh roleandfunctionofrasassociationdomainfamilyincancerareview AT seyedalimomeni roleandfunctionofrasassociationdomainfamilyincancerareview AT peymankheirandishzarandi roleandfunctionofrasassociationdomainfamilyincancerareview AT ghanbarmahmoodichalbatani roleandfunctionofrasassociationdomainfamilyincancerareview AT hassandana roleandfunctionofrasassociationdomainfamilyincancerareview AT hamidrezamirzaei roleandfunctionofrasassociationdomainfamilyincancerareview AT mohammadesmaeilakbari roleandfunctionofrasassociationdomainfamilyincancerareview AT seyedrouhollahmiri roleandfunctionofrasassociationdomainfamilyincancerareview |