Inhibition of Hsp110-STAT3 interaction in endothelial cells alleviates vascular remodeling in hypoxic pulmonary arterial Hypertension model

Inhibition of Hsp110-STAT3 interaction in endothelial cells alleviates vascular remodeling in hypoxic pulmonary arterial Hypertension model

Abstract Background Pulmonary arterial hypertension (PAH) is a progressive and devastating disease characterized by pulmonary vascular remodeling which is associated with the malignant phenotypes of pulmonary vascular cells. Recently, the effects of heat shock protein 110 (Hsp110) in human arterial...

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Bibliographic Details
Main Authors: Congke Zhao, Xiangyang Le, Mengqi Li, Yuanbo Hu, Xiaohui Li, Zhuo Chen, Gaoyun Hu, Liqing Hu, Qianbin Li
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Respiratory Research
Subjects:
Pulmonary arterial Hypertension
Vascular remodeling
Heat shock protein 110
Protein-protein interaction
Pulmonary arterial endothelial cell
Online Access:https://doi.org/10.1186/s12931-023-02600-5

Internet

https://doi.org/10.1186/s12931-023-02600-5

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