Glabridin, a Bioactive Flavonoid from Licorice, Effectively Inhibits Platelet Activation in Humans and Mice

Glabridin, a Bioactive Flavonoid from Licorice, Effectively Inhibits Platelet Activation in Humans and Mice

Platelets are crucial for hemostasis and arterial thrombosis, which may lead to severe cardiovascular diseases (CVDs). Thus, therapeutic agents must be developed to prevent pathological platelet activation. Glabridin, a major bioalkaloid extracted from licorice root, improves metabolic abnormalities...

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Bibliographic Details
Main Authors: Chi-Li Chung, Jui-Hsuan Chen, Wei-Chieh Huang, Joen-Rong Sheu, Chih-Wei Hsia, Thanasekaran Jayakumar, Chih-Hsuan Hsia, Kuan-Rau Chiou, Shaw-Min Hou
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
glabridin
platelet
MAPK
microvascular thrombosis
PI3K/Akt/GSK3β
PLCγ2/PKC
Online Access:https://www.mdpi.com/1422-0067/23/19/11372

Internet

https://www.mdpi.com/1422-0067/23/19/11372

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