Bone Progenitors Pull the Strings on the Early Metabolic Rewiring Occurring in Prostate Cancer Cells

Bone Progenitors Pull the Strings on the Early Metabolic Rewiring Occurring in Prostate Cancer Cells

Metastatic prostate cancer (PCa) cells soiling in the bone require a metabolic adaptation. Here, we identified the metabolic genes fueling the seeding of PCa in the bone niche. Using a transwell co-culture system of PCa (PC3) and bone progenitor cells (MC3T3 or Raw264.7), we assessed the transcripto...

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Bibliographic Details
Main Authors: Pablo Sanchis, Nicolas Anselmino, Sofia Lage-Vickers, Agustina Sabater, Rosario Lavignolle, Estefania Labanca, Peter D. A. Shepherd, Juan Bizzotto, Ayelen Toro, Antonina Mitrofanova, Maria Pia Valacco, Nora Navone, Elba Vazquez, Javier Cotignola, Geraldine Gueron
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cancers
Subjects:
prostate cancer
bone metastasis
metabolism
gene signature
lipid metabolism
PKA
Online Access:https://www.mdpi.com/2072-6694/14/9/2083

Internet

https://www.mdpi.com/2072-6694/14/9/2083

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