Differential Mechanisms of Septic Human Pulmonary Microvascular Endothelial Cell Barrier Dysfunction Depending on the Presence of Neutrophils

Differential Mechanisms of Septic Human Pulmonary Microvascular Endothelial Cell Barrier Dysfunction Depending on the Presence of Neutrophils

Sepsis is characterized by injury of pulmonary microvascular endothelial cells (PMVEC) leading to barrier dysfunction. Multiple mechanisms promote septic PMVEC barrier dysfunction, including interaction with circulating leukocytes and PMVEC apoptotic death. Our previous work demonstrated a strong co...

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Bibliographic Details
Main Authors: Lefeng Wang, Sanjay Mehta, Yousuf Ahmed, Shelby Wallace, M. Cynthia Pape, Sean E. Gill
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
human sepsis
endothelial barrier dysfunction
neutrophil
caspase activity
cell co-culture
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01743/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01743/full

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