Aryloxyalkanoic Acids as Non-Covalent Modifiers of the Allosteric Properties of Hemoglobin

Aryloxyalkanoic Acids as Non-Covalent Modifiers of the Allosteric Properties of Hemoglobin

Hemoglobin (Hb) modifiers that stereospecifically inhibit sickle hemoglobin polymer formation and/or allosterically increase Hb affinity for oxygen have been shown to prevent the primary pathophysiology of sickle cell disease (SCD), specifically, Hb polymerization and red blood cell sickling. Severa...

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Bibliographic Details
Main Authors: Abdelsattar M. Omar, Mona A. Mahran, Mohini S. Ghatge, Faida H. A. Bamane, Mostafa H. Ahmed, Moustafa E. El-Araby, Osheiza Abdulmalik, Martin K. Safo
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Molecules
Subjects:
hemoglobin
sickle cell disease
aryloxyalkanoic acids
halogenated benzene
imidazole
antisickling
oxygen equilibrium curve
high affinity
low affinity
crystal structure
Online Access:http://www.mdpi.com/1420-3049/21/8/1057

Internet

http://www.mdpi.com/1420-3049/21/8/1057

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