Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology

Abstract Background The brain predominantly expressed RING finger protein, Znf179, is known to be important for embryonic neuronal differentiation during brain development. Downregulation of Znf179 has been observed in motor neurons of adult mouse models for amyotrophic lateral sclerosis (ALS), yet...

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Bibliographic Details
Main Authors: Yi-Chao Lee, Wan-Chen Huang, Jiann-Her Lin, Tzu-Jen Kao, Hui-Ching Lin, Kuen-Haur Lee, Hsin-Chuan Lin, Che-Kun James Shen, Wen-Chang Chang, Chi-Chen Huang
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Biomedical Science
Subjects:
Znf179
TDP-43
Polyubiquitination
E3 ligase
ALS
FTLD-U
Online Access:http://link.springer.com/article/10.1186/s12929-018-0479-4

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http://link.springer.com/article/10.1186/s12929-018-0479-4

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