Human J-Domain Protein DnaJB6 Protects Yeast from [<i>PSI</i><sup>+</sup>] Prion Toxicity

Human J-Domain Protein DnaJB6 Protects Yeast from [<i>PSI</i><sup>+</sup>] Prion Toxicity

Human J-domain protein (JDP) DnaJB6 has a broad and potent activity that prevents formation of amyloid by polypeptides such as polyglutamine, A-beta, and alpha-synuclein, related to Huntington’s, Alzheimer’s, and Parkinson’s diseases, respectively. In yeast, amyloid-based [<i>PSI<sup>+&l...

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Bibliographic Details
Main Authors: Richard E. Dolder, Jyotsna Kumar, Michael Reidy, Daniel C. Masison
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Biology
Subjects:
DnaJB6
J-domain proteins
amyloid
amyloid toxicity
yeast prions
Online Access:https://www.mdpi.com/2079-7737/11/12/1846

Internet

https://www.mdpi.com/2079-7737/11/12/1846

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