Inducible HEK293 AAV packaging cell lines expressing Rep proteins

Inducible HEK293 AAV packaging cell lines expressing Rep proteins

Packaging or producer cell lines for scalable recombinant adeno-associated virus (rAAV) production have been notoriously difficult to create due in part to the cytostatic nature of the Rep proteins required for AAV production. The most difficult challenge being creating AAV packaging cell lines usin...

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Bibliographic Details
Main Authors: Lovro Jalšić, Viktoria Lytvyn, Seyyed Mehdy Elahi, Sabahudin Hrapovic, Nasha Nassoury, Parminder Singh Chahal, Bruno Gaillet, Rénald Gilbert
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
packaging cell
HEK293
inducible expression
Rep
manufacturing
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123001079

Internet

http://www.sciencedirect.com/science/article/pii/S2329050123001079

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