Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia

Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia

An elevated neutrophil–lymphocyte ratio negatively predicts the outcome of patients with cancer and is associated with cachexia, the terminal wasting syndrome. Here, using murine model systems of colorectal and pancreatic cancer we show that neutrophilia in the circulation and multiple organs, accom...

Full description

Bibliographic Details
Main Authors: Michele Petruzzelli, Miriam Ferrer, Martijn J. Schuijs, Sam O. Kleeman, Nicholas Mourikis, Zoe Hall, David Perera, Shwethaa Raghunathan, Michele Vacca, Edoardo Gaude, Michael J. Lukey, Duncan I. Jodrell, Christian Frezza, Erwin F. Wagner, Ashok R. Venkitaraman, Timotheus Y. F. Halim, Tobias Janowitz
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cancers
Subjects:
cancer
cachexia
metabolism
host
neutrophils
aerobic glycolysis
Online Access:https://www.mdpi.com/2072-6694/14/4/963

Internet

https://www.mdpi.com/2072-6694/14/4/963

Similar Items