Determining the effects of trastuzumab, cetuximab and afatinib by phosphoprotein, gene expression and phenotypic analysis in gastric cancer cell lines

Determining the effects of trastuzumab, cetuximab and afatinib by phosphoprotein, gene expression and phenotypic analysis in gastric cancer cell lines

Abstract Background Gastric cancer is the fifth most frequently diagnosed cancer and the third leading cause of cancer death worldwide. The molecular mechanisms of action for anti-HER-family drugs in gastric cancer cells are incompletely understood. We compared the molecular effects of trastuzumab a...

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Bibliographic Details
Main Authors: Karolin Ebert, Gwen Zwingenberger, Elena Barbaria, Simone Keller, Corinna Heck, Rouven Arnold, Vanessa Hollerieth, Julian Mattes, Robert Geffers, Elba Raimúndez, Jan Hasenauer, Birgit Luber
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Cancer
Subjects:
Trastuzumab
Cetuximab
Afatinib
Gastric cancer
Motility
Phosphoprotein
Online Access:http://link.springer.com/article/10.1186/s12885-020-07540-7

Internet

http://link.springer.com/article/10.1186/s12885-020-07540-7

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