Homocysteine aggravates ROS-induced depression of transmitter release from motor nerve terminals: potential mechanism of peripheral impairment in motor neuron diseases associated with hyperhomocysteinemia

Homocysteine aggravates ROS-induced depression of transmitter release from motor nerve terminals: potential mechanism of peripheral impairment in motor neuron diseases associated with hyperhomocysteinemia

Homocysteine (HCY) is a pro-inflammatory sulphur-containing redox active endogenous amino acid, which concentration increases in neurodegenerative disorders including amyotrophic lateral sclerosis (ALS). A widely held view suggests that HCY could contribute to neurodegeneration via promotion of oxid...

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Bibliographic Details
Main Authors: Ellya eBukharaeva, Anastasia eShakirzyanova, Venera eKhuzakhmetova, Guzel eSitdikova, Rashid eGiniatullin
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Amyotrophic Lateral Sclerosis
Homocysteine
Neuromuscular Junction
Oxidative Stress
NMDA receptors.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00391/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00391/full

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