Tissue Inhibitor of Metalloproteinases-1 Interacts with CD74 to Promote AKT Signaling, Monocyte Recruitment Responses, and Vascular Smooth Muscle Cell Proliferation

Tissue Inhibitor of Metalloproteinases-1 Interacts with CD74 to Promote AKT Signaling, Monocyte Recruitment Responses, and Vascular Smooth Muscle Cell Proliferation

Tissue inhibitor of metalloproteinases-1 (TIMP-1), an important regulator of matrix metalloproteinases (MMPs), has recently been shown to interact with CD74, a receptor for macrophage migration inhibitory factor (MIF). However, the biological effects mediated by TIMP-1 through CD74 remain largely un...

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Bibliographic Details
Main Authors: Simon Ebert, Lan Zang, Noor Ismail, Michael Otabil, Adrian Fröhlich, Virginia Egea, Susann Ács, Mikkel Hoeberg, Marie-Luise Berres, Christian Weber, José M. A. Moreira, Christian Ries, Jürgen Bernhagen, Omar El Bounkari
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
cytokine
chemokine
cell migration/adhesion
proliferation
vascular inflammation
atherogenesis
Online Access:https://www.mdpi.com/2073-4409/12/14/1899

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https://www.mdpi.com/2073-4409/12/14/1899

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