Tetrahydroisoquinoline-Triazole Derivatives: Novel Nicotinamide <i>N</i>-Methyltransferase Inhibitors

Tetrahydroisoquinoline-Triazole Derivatives: Novel Nicotinamide <i>N</i>-Methyltransferase Inhibitors

Through the Lilly Open Innovation Drug Discovery program (OIDD), we discovered five cationic bis(aryltriazol-4-yl)methyl)-6,7-dimethoxytetrahydroisoquinolinium derivatives that effectively inhibit human nicotinamide N-methyltransferase. Compounds <b>4a</b>, <b>4c</b>, and <...

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Bibliographic Details
Main Authors: Alison T. Ung, Matthew Payne
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:AppliedChem
Subjects:
bis(phenyl-triazolyl)-dimethoxytetrahydroisoquinolinium
hNNMT inhibitors
<i>S</i>-adenosyl-L-methionine (SAM)
nicotinamide (NA)
SAR
resistant cancers
Online Access:https://www.mdpi.com/2673-9623/3/4/32

Internet

https://www.mdpi.com/2673-9623/3/4/32

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