Tetrahydroisoquinoline-Triazole Derivatives: Novel Nicotinamide <i>N</i>-Methyltransferase Inhibitors

Tetrahydroisoquinoline-Triazole Derivatives: Novel Nicotinamide <i>N</i>-Methyltransferase Inhibitors

Through the Lilly Open Innovation Drug Discovery program (OIDD), we discovered five cationic bis(aryltriazol-4-yl)methyl)-6,7-dimethoxytetrahydroisoquinolinium derivatives that effectively inhibit human nicotinamide N-methyltransferase. Compounds <b>4a</b>, <b>4c</b>, and <...

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Bibliographic Details
Main Authors:	Alison T. Ung, Matthew Payne
Format:	Article
Language:	English
Published:	MDPI AG 2023-11-01
Series:	AppliedChem
Subjects:	bis(phenyl-triazolyl)-dimethoxytetrahydroisoquinolinium hNNMT inhibitors <i>S</i>-adenosyl-L-methionine (SAM) nicotinamide (NA) SAR resistant cancers
Online Access:	https://www.mdpi.com/2673-9623/3/4/32

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