Fine tuning of the net charge alternation of polyzwitterion surfaced lipid nanoparticles to enhance cellular uptake and membrane fusion potential

Fine tuning of the net charge alternation of polyzwitterion surfaced lipid nanoparticles to enhance cellular uptake and membrane fusion potential

Lipid nanoparticles (LNPs) coated with functional and biocompatible polymers have been widely used as carriers to deliver oligonucleotide and messenger RNA therapeutics to treat diseases. Poly(ethylene glycol) (PEG) is a representative material used for the surface coating, but the PEG surface-coate...

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Bibliographic Details
Main Authors: Keitaro Homma, Yutaka Miura, Motoaki Kobayashi, Wanphiwat Chintrakulchai, Masahiro Toyoda, Koichi Ogi, Junya Michinishi, Tomoyuki Ohtake, Yuto Honda, Takahiro Nomoto, Hiroyasu Takemoto, Nobuhiro Nishiyama
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Science and Technology of Advanced Materials
Subjects:
Lipid nanoparticles
siRNA
polycarboxybetaine
membrane fusion
pH-responsiveness
Online Access:https://www.tandfonline.com/doi/10.1080/14686996.2024.2338785

Internet

https://www.tandfonline.com/doi/10.1080/14686996.2024.2338785

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