Tonic GABAA conductance decreases membrane time constant and increases EPSP-spike precision in hippocampal pyramidal neurons

Tonic GABAA conductance decreases membrane time constant and increases EPSP-spike precision in hippocampal pyramidal neurons

Because of a complex dendritic structure, pyramidal neurons have a large membrane surface relative to other cells and so a large electrical capacitance and a large membrane time constant (τm). This results in slow depolarizations in response to excitatory synaptic inputs, and consequently increased...

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Bibliographic Details
Main Authors: Agnieszka I Wlodarczyk, Chun eXu, Inseon eSong, Maxim eDoronin, Yu-Wei eWu, Matthew eWalker, Alexey eSemyanov
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Neural Circuits
Subjects:
Hippocampus
GABA
pyramidal neuron
spike jitter
EPSP-spike precision
tonic conductance
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00205/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00205/full

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