Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex

Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex

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Disrupting the formation of the oncogenic YAP/TAZ-TEAD transcriptional complex holds substantial therapeutic potential. However, the three protein interaction interfaces of this complex cannot be easily disrupted using small molecules. Here, we report that the pharmacologically active small molecule...

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Bibliographic Details
Main Authors: Kepeng Che, Ajaybabu V. Pobbati, Caleb N. Seavey, Yuriy Fedorov, Anton A. Komar, Ashley Burtscher, Shuang Ma, Brian P. Rubin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007350/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007350/?tool=EBI

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