The STING/TBK1/IRF3/IFN type I pathway is defective in cystic fibrosis

The STING/TBK1/IRF3/IFN type I pathway is defective in cystic fibrosis

Cystic fibrosis (CF) is a rare autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The most common mutation is F508del-CFTR (ΔF) which leads the encoded ion channel towards misfolding and premature degradation. The disease is charac...

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Bibliographic Details
Main Authors: Luca Occhigrossi, Federica Rossin, Valeria Rachela Villella, Speranza Esposito, Carlo Abbate, Manuela D’Eletto, Maria Grazia Farrace, Antonella Tosco, Roberta Nardacci, Gian Maria Fimia, Valeria Raia, Mauro Piacentini
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
cystic fibrosis
bacterial infections
innate immune response
STING pathway
type I interferon
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1093212/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1093212/full

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