Hesperetin from Root Extract of <i>Clerodendrum petasites</i> S. Moore Inhibits SARS-CoV-2 Spike Protein S1 Subunit-Induced NLRP3 Inflammasome in A549 Lung Cells via Modulation of the Akt/MAPK/AP-1 Pathway

Hesperetin from Root Extract of <i>Clerodendrum petasites</i> S. Moore Inhibits SARS-CoV-2 Spike Protein S1 Subunit-Induced NLRP3 Inflammasome in A549 Lung Cells via Modulation of the Akt/MAPK/AP-1 Pathway

Inhibition of inflammatory responses from the spike glycoprotein of SARS-CoV-2 (Spike) by targeting NLRP3 inflammasome has recently been developed as an alternative form of supportive therapy besides the traditional anti-viral approaches. <i>Clerodendrum petasites</i> S. Moore (<i>...

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Bibliographic Details
Main Authors: Punnida Arjsri, Kamonwan Srisawad, Sariya Mapoung, Warathit Semmarath, Pilaiporn Thippraphan, Sonthaya Umsumarng, Supachai Yodkeeree, Pornngarm Dejkriengkraikul
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
NLRP3 inflammasome
chronic inflammation
<i>Clerodendrum petasites</i>
hesperetin
anti-inflammation
spike glycoprotein S1
Online Access:https://www.mdpi.com/1422-0067/23/18/10346

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https://www.mdpi.com/1422-0067/23/18/10346

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